Chronic Fatigue Syndrome Home > MSM Side Effects

Nausea, bloating, and fatigue are some of the side effects that have been reported with MSM. Side effects that are unpredictable are also possible due to contaminants in the product, as dietary supplements are sometimes contaminated with other herbs, medications, or even heavy metals. If you develop any bothersome side effects of MSM, be sure to contact your healthcare provider immediately.

Does MSM Cause Side Effects?

MSM (methylsulfonylmethane) is a naturally occurring compound found in many foods. It is also a popular dietary supplement. As with most dietary supplements, there is a lack of clear, quality information regarding the possible MSM side effects, since supplements are not typically thoroughly studied.
(This article covers many, but not all, of the possible side effects with MSM. Your healthcare provider can discuss a more complete list of MSM side effects with you.)

Possible Side Effects of MSM

A few clinical studies have reported side effects with MSM, although these side effects were just as common in people taking a placebo (a "sugar pill"). These possible side effects included:


    • A rash or hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.


Be sure to seek immediate medical attention if you think you may be having an allergic reaction to MSM.
Unpredictable MSM side effects are also possible due to contaminants in MSM products. Because herbs and supplements are not as tightly regulated as prescription or non-prescription drugs, they are sometimes contaminated with other herbs, medications, or even heavy metals. In order to avoid such problems, it is important to choose a high-quality supplement from a trustworthy manufacturer.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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